Anna Marie Pyle

Member of the American Academy of Arts and Sciences

Investigator at Howard Hughes Medical Institute, Yale University

Anna Marie Pyle is the William Edward Gilbert Professor of Molecular, Cellular and Developmental Biology and professor of chemistry at Yale University. She has been a Howard Hughes Medical Institute Investigator since 1997. Dr. Pyle obtained her undergraduate degree in chemistry from Princeton University and received her PhD in chemistry from Columbia University, where she worked with Professor Jacqueline K. Barton, in 1990.

She pioneered the study of RNA helicase enzymes and other RNA-stimulated ATPases that serve as translocases, RNA remodeling enzymes, and sensors of pathogenic RNA. Her studies are complemented by efforts to develop RNA and small molecule modulators of innate immune functions and antiviral response.

Pyle studies RNA structure and RNA recognition by protein enzymes. Her lab uses a combination of experimental biochemistry and crystallography to study the architectural features of large RNA molecules, such as self-splicing introns and other noncoding RNAs. This is accompanied by complementary work on RNA-dependent ATPase enzymes that bind and remodel RNA structures, with an emphasis on proteins that are involved in viral replication and host innate immune response.

Sources from the Pyle Lab at Yale University: https://pylelab.org/people/anna-marie-pyle