PH.D., Professor, CASM

The Institute of Cancer and Basic Medicine, CAS, China

Resume

1964-1970 
B. S., Department of Precision Instrument, Tsinghua University. 
1978-1981 
M.S., Department of Engineering Physics, Tsinghua University. 
1985-1988 
Ph.D., Biophysics Institute, Technical University Munich. 
1989-1991 
Associate Professor, Department of Biological Sciences and Biotechnology, Tsinghua University. 
1991.01-present 
Professor, School of Life Sciences (replacing the Department of Biological Sciences and Biotechnology in September of 2009 ), Tsinghua University. 

Research interest

Using cryo-electron microscopy (cryo-EM) in combination with biochemical, biophysical and cellular methods, our lab currently focuses on: (1) structures, functions and mechanisms of large protein complexes, macromolecular machines and membrane proteins, and (2) molecular mechanisms of membrane trafficking, lipid-protein interactions and membrane-related human diseases.

Selected Publications

1. Ma J, You X, Sun S, Wang X, Qin S, Sui SF*. (2020) Structural basis of energy transfer in Porphyridium purpureum phycobilisome. Nature, 579(7797):146-151. 
2. Pi X, Zhao S, Wang W, Liu D, Xu C, Han G, Kuang T*, Sui SF*, Shen JR*. (2019) The pigment-protein network of a diatom photosystem II-light-harvesting antenna supercomplex. Science, 365(6452). pii: eaax4406. 
3. Huang X, Sun S, Wang X, Fan F, Zhou Q, Lu S, Cao Y, Wang QW, Dong MQ, Yao J, Sui SF*.（2019）Mechanistic insights into the SNARE complex disassembly. Sci Adv.,5(4). 
4. Qin X, Pi X, Wang W, Han G, Zhu L, Liu M, Cheng L, Shen JR, Kuang T*, Sui SF*. (2019) Structure of a green algal photosystem I in complex with a large number of light-harvesting complex I subunits. Nat Plants, 5(3):263-272. 
5. Pi X, Tian L, Dai HE, Qin X, Cheng L, Kuang T, Sui SF*, Shen JR*. (2018) Unique organization of photosystem I-light-harvesting supercomplex revealed by cryo-EM from a red alga. Proc Natl Acad Sci USA, 115(17):4423-4428. 
6. Yang X, Yang F, Wang W, Lin G, Hu Z, Han Z, Qi Y, Zhang L, Wang J, Sui SF*, Chai J*. (2018) Structural basis for specific flagellin recognition by the NLR protein NAIP5. Cell Research, 28(1):35-47. 
7. Zhang J, Ma J, Liu D, Qin S, Sun S*, Zhao J, Sui SF*. (2017) Structure of phycobilisome from the red alga Griffithsia pacifica. Nature, 551(7678):57-63. 8. 
8. Sun S, Li L, Yang F, Wang X, Fan F, Yang M, Chen C, Li X, Wang HW, Sui SF*. (2017) Cryo-EM structures of the ATP-bound Vps4-E233Q hexamer and its complex with Vta1 at near-atomic resolution. Nat Commun., 8:16064. 
9. Hu Z, Zhou Q, Zhang C, Fan S, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF*, Chai J*. (2015) Structural and Biochemical Basis for Induced Self-propagation of NLRC4. Science, 350(6259):399-404. 
10. Chang L, Liu X, Li Y, Liu CC, Yang F, Zhao J*, Sui SF*. (2015) Structural organization of an intact phycobilisome and its association with photosystem II. Cell Research, 25(6):726-737.