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Zijiang Chen

Updated: 2021-09-03


MD, Obstetrician/Gynecologist, CASM

Shandong University


Dr. Chen received her bachelor-equivelent medical education at School of Medicine Shandong University (previously the Shandong Medical College), and got her MD–PhD in 1989 majoring in Obstetrics and Gynecology. As the youngest professor in the school’s history, Dr. Chen joined the faculty of School of Medicine Shandong University, where she was promoted to full professor in 1993 and has continued to work there ever since. Between 1996 and 1999, Dr. Chen fisrt worked at the Cleveland Clinic Foundation (USA) as an International Scholar, and then as a postdoctoral fellow at Case Western Reserve University (CWRU). From 1999 to 2005, Dr. Chen served as faculty at the Department of Medicine CWRU.

Research Areas and Honors

Dr. Chen’s career is characterized by numerous transformative and original findings which are evidenced by more than 200 peer-reviewed articles as the corresponding author in journals including N Engl J Med, Lancet, Nature, Cell, Nat Genet, etc. Dr. Chen is currently the chief scientist of a national key scientific research program (973 Program) in China, the supervisor of the national outstanding doctoral degree thesis program, the chairman of the Gynecologic Endocrine Group of the Chinese Medical Association, and the Secretary General of the International Federation of Fertility Societies (IFFS). Dr. Chen has won the second prize of National Scientific and Technological Progress Awards for three times (2009, 2010, and 2015), and the Ho Leung Ho Lee Foundation Achievement Award (2012). She has also been invited to present keynote speeches in many international conferences, including those organized by the IFFS, FIGO, WARM, and ESHRE because of her outstanding work in research and clinics.

Currently, Dr. Chen works as a leading clinical researcher and physician in obstetrics, gynecology and reproductive medicine, focusing on reproductive health, birth defects, major reproductive and endocrine diseases, as well as infertility. Her studies cover the etiology and mechanisms of infertility, polycystic ovary syndrome (PCOS), premature ovarian failure (POF) and other major reproductive disorders, the activation mechanisms of the human embryonic genome, and the three-dimensional dynamics regulating chromatin organization. She has advanced the understanding of the establishment of chromatin structure during mammalian embryonic development. In addition, she owns patents of several innovative clinical technologies for assisted reproduction and birth defect prevention. She had also led a series of multi-center clinical trials on critical issues in assisted reproduction.

Selected publications

1、Wan, Ji-Peng; Wang, Hong; Li, Chang-Zhong; Zhao, Han; You, Li; Shi, Dong-Hong; Sun, Xiu-Hua; Lv, Hong; Wang, Fei; Wen, Ze-Qing; *Wang, Xie-Tong;Chen, Zi-Jiang,The Common Single-Nucleotide Polymorphism rs2681472 Is Associated With Early-Onset Preeclampsia in Northern Han Chinese Women, Reproductive Sciences, 21(11), pp 1423-1427, 2014/11. 

2、Song, Guihong; Yan, Junhao; Zhang, Qian; Li, Guangyu;*Chen, Zi-Jiang,Association of tissue inhibitor of metalloproteinase gene polymorphisms and unexplained recurrent spontaneous abortions in Han Chinese couples, European Journal of Obstetrics & Gynecology and Reproductive Biology, 181卷, pp 84-88, 2014/10.  

3、Zhang, Wenchao; *Cheng, Zhongping; Qu, Xiaoyan; Dai, Hong; Ke, Xiaoping;Chen, Zijiang,Overexpression of myosin is associated with the development of uterine myoma, Journal of Obstetrics and Gynaecology Research, 40(9), pp 2051-2057, 2014/9. 

4、Du, Jing; Wang, Jianfeng; Sun, Xuedong; Xu, Xinghua; Zhang, Feng; Wang, Bin; *Shi, Yuhua;Chen, Zi-jiang,Family-based analysis of INSR polymorphisms in Chinese PCOS, Reproductive BioMedicine Online, 29(2), pp 239-244, 2014/8.  

5、Guo, Ting; Qin, Yingying; Jiao, Xue; Li, Guangyu; Simpson, Joe Leigh;*Chen, Zi-Jiang,FMR1 Premutation Is an Uncommon Explanation for Premature Ovarian Failure in Han Chinese, PLos One, 9(7), 2014/7/22.  

6、Wu, Keliang; Zheng, Ye; Zhu, Yueting; Li, Hongchang; Yu, Guanling; *Yan, Junhao;Chen, Zi-Jiang,Morphological good-quality embryo has higher nucleus spreading rate/signal resolution rate in fluorescence in situ hybridization, Archives of Gynecology and Obstetrics, 290(1), pp 185-190, 2014/7. 

7、Cui, Y.; Ma, Z.; Zhao, H.; Chen, X.; Zhang, Y.; Guo, H.; *Zhao, Y.;Chen, Z. -J.,Activation of eIF2 alpha Signaling Cascade is Associated with Testosterone-Induced Cell Apoptosis in INS-1 Cells, Hormone and Metabolic Research, 46(8), pp 574-580, 2014/7.  

8、Zhang, Qian; Yan, Junhao; Tang, Rong; Gao, Xuan; Zhang, Bo;*Chen, Zi-Jiang,Serum Human Chorionic Gonadotropin Level Measured 17 Days After Oocyte Retrieval Can Predict Final Clinical Pregnancy Outcomes in IVF/ICSI Treatment Cycles, Journal of Reproductive Medicine, 59(5-6), pp 285-292, 2014/6 MAY-JUN. 

9、Shi, Yuhua; Wei, Daimin; Liang, Xiaoyan; Sun, Yun; Liu, Jiayin; Cao, Yunxia; Zhang, Bo; Legro, Richard S.; Zhang, Heping;*Chen, Zi-Jiang,Live birth after fresh embryo transfer vs elective embryo cryopreservation/frozen embryo transfer in women with polycystic ovary syndrome undergoing IVF (FreFro-PCOS): study protocol for a multicenter, prospective, randomized controlled clinical trial, Trials, 15卷, 2014/5/2. 

10、Zhang, Wenjuan; Wei, Daimin; Sun, Xianchang; Li, Jing; Yu, Xinyan; *Shi, Yuhua;Chen, Zi-jiang,Family-based analysis of adiponectin gene polymorphisms in Chinese Han polycystic ovary syndrome, Fertility and Sterility, 101(5), pp 1419-U51, 2014/5.