Dinshaw J. Patel

Ph.D., Professor, MNAS, AAAS

Memorial Sloan-Kettering Cancer Center, USA

Main research fields

The Patel laboratory applies cryo-EM, x-ray crystallographic and biochemical approaches to the study of macromolecular recognition, regulation and catalysis. Ongoing projects include structure-function studies of the CRISPR-Cas and cGAS-STING surveillance pathways, the role of structural maintenance of chromosomes complexes in mediating DNA double strand break repairs, the role of histone and DNA methylation in epigenetic regulation, and RNA-mediated processes ranging from riboswitches and ribozymes to those governing siRNA and piRNA pathways.