From simple and primitive microorganisms up to complex and advanced organisms such as animals and plants, since their emergence and existence, have all perceived the complex and varied living environment around them, and transmitted the environmental information perceived by their bodies to their information processing centers for processing and making corresponding responses to avoid damage and harm from adverse environments. They have adapted to the environment to better survive. If organisms fail to make adaptive responses to environmental information, they may face abnormalities, functional disorders, diseases, and even death. The perception of abnormal tissue functions by organisms and the targeted delivery and treatment of therapeutic drugs are closely related to the processes of biological perception and sensing. 

This session focuses on the latest research progress and frontiers in the perception, transmission and regulation of external and endogenous signals, as well as the intervention mechanisms of functional abnormalities in living organisms from the perspectives of biological macromolecules, subcellular structures, cells, and individuals. 

Chairs

Liu Jianfeng

Xu Guangyin

Invited speakers & reports

Kong Wei

Professor, Peking University Health Science Center

Report: Discovery of G protein-coupled receptors and their new ligands 

Zhang Xiaobing

Professor, Hunan University

Report: Structural regulation and precision imaging of spectroscopic probes 

Xu Chanjuan

Huazhong University of Science and Technology

Report: Different pharmacological and Gi/o protein responses triggered by endogenous GPCRs in neurons

Xu Fei    

ShanghaiTech University

Report: A framework for class-A GPCR dimerization

Shao Zhenhua     

West China Hospital, Sichuan University

Report: Allosteric regulation and disease intervention of GPCR signal transduction

Qiu Liping

Professor, Hunan University

Report: Spatio-temporal specific measurement of cell membrane molecules

Ye Mao

Professor, Hunan University

Report: Elucidation of CKAP4-remodeled cell mechanics in driving metastasis of bladder cancer through aptamers 

Xu Xianghui

Professor, Hunan University

Report: Biosensory biomimetic peptide nanodrugs and targeted therapy

Chen Zhongwen  

Shanghai Institute of Organic Chemistry, CAS

Report: Physical chemical regulation of cell membrane signaling