Understanding human health at single-molecule level and providing solutions for diseases require efforts to conduct interdisciplinary scientific research.

In the past year, scientific research has propelled the forefront of single-molecule science forward with remarkable progress. Through single-molecule mechanical techniques, scientists have been actively tracking the mutation and evolution of novel coronaviruses, while unraveling the stability of interactions between the virus and human lungs.

Additionally, high-speed atomic force microscopy has unveiled the dynamic transition of TRP ion channels from tetramers to pentamers, breaking new ground for drug development.

Moreover, investigations into the molecular motors of SMC protein complexes have illuminated their capacity to generate DNA loops and dynamically remodel the chromatin structure in eukaryotes. Delving deeper into the realm of molecular biology, recent studies have shed light on new mechanisms underlying human mRNA decoding and recoding.

Furthermore, single-molecule studies have elucidated the highly dynamic nature of biomolecular condensation and unveiled the instantaneous dynamics of glycolipid transfer through single-molecule tracking techniques.

This intersectional research on single-molecule biophysics and chemistry is fostering a deeper comprehension of human health among the general public.

Chairs

Long Mian

Researcher, Institute of Mechanics, Chinese Academy of Sciences (CAS)

Guo Xuefeng

Professor, Peking University (PKU)

Invited speakers & reports

Yan Jie

Professor, National University of Singapore

Report: Unveiling mechanosensing mechanisms of proteins through AI-based structural prediction and single-molecule manipulation

Tian Jie

Professor, Beihang University

Report: AI and biological big data accelerate the translation from basic research to clinical applications

Chen Liangyi

Professor, PKU

Report: Single-molecule super-resolution light-field microscopy

Zhou Jing

Professor, PKU

Report: Discoidin domain receptor 1: An emerged novel mechanosensor

Chen Chunlai

Professor, Tsinghua University

Report: AI-assisted single-molecule fluorescence signal enhancement and screening

Jia Chuancheng

Professor, Nankai University

Report: Single-molecule device-based research on single-molecule bioelectronics

Lu Ying

Researcher, Institute of Physics, CAS

Report: Self-limiting aggregation of α-synuclein protein on lipid membranes

Chen Xiuqi    

Delft University of Technology

Report: Single-molecule protein sequencing with nanopores 

Yu Hao  

Huazhong University of Science and Technology

Report: Transcriptional intermediates enable higher dynamic range for SAM-I riboswitches 

Fan Jun  

University of Electronic Science and Technology of China

Report: Single-molecule tracking of transcription and DNA repair in living bacterial cells

Tang Aihui

University of Science and Technology of China

Report: Using MINFLUX nanoscopy to analyze the single-molecule dynamics of AMPA receptors in neural synapses 

Liu Wei  

Leica Microsystems (Shanghai) Trading Co Ltd

Report: From high-resolution imaging and precise sampling to high-accuracy analysis – Leica's omics solutions facilitate spatial multi-omics research